SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF QUERCETIN AND 2-METHYLIMIDAZOLE MIXED-LIGAND COBALT(II) AND NICKEL(II) COMPLEXES
| dc.contributor.author | Abdullahi O. Rajee, Kareemat T. Adesope, Sheriff O. Ayinla, Haizat O. Sa'ad, Abdulbasit A. Aliyu, Omotola E. Tajudeen, Feyisetan Ogunmoroti | |
| dc.date.accessioned | 2026-05-02T05:27:00Z | |
| dc.date.available | 2026-05-02T05:27:00Z | |
| dc.date.issued | 2025-12 | |
| dc.description.abstract | Two new mixed-ligand complexes, [Co(Que)₂(2-MeIm)₂] and [Ni(Que)₂(2-MeIm)₂], were synthesized and characterized by elemental analysis, FTIR, UV-Vis, TGA, magnetic susceptibility, and molar conductance measurements. Quercetin coordinates as a dianionic bidentate O,O-donor, while 2-methylimidazole acts as a neutral monodentate N-donor, yielding anhydrous octahedral geometries (μeff = 4.81 B.M. for Co(II); 3.14 B.M. for Ni(II)). Both complexes exhibited markedly enhanced antimicrobial activity against Gram-positive (S. aureus), Gram-negative (E. coli, K. pneumoniae, P. aeruginosa), and fungal (A. niger) strains compared to free ligands, with zones of inhibition reaching 17–22 mm at 200 mg/mL (vs. 8–14 mm for ligands). The results validate the beneficial role of metal coordination in improving the lipophilicity and biological performance of quercetin-based systems. | |
| dc.identifier.citation | 15. Rajee, A. O., Adesope, K. T., Ayinla, S. O., Saadu, H. O., Aliyu, A.A., Tajudeen, O.E., & Ogunmoroti, F. (2025). Synthesis, spectroscopic characterisation, and antimicrobial evaluation of Quercetin and 2-methylimidazole mixed-ligand cobalt(II) and nickel(II) complexes. AAU J. Physical & Applied Sciences. 5(2), 5-16. | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/17886 | |
| dc.publisher | Faculty of Physical Science (FPS), Ambrose Alli University, Ekpoma, Nigeria | |
| dc.title | SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF QUERCETIN AND 2-METHYLIMIDAZOLE MIXED-LIGAND COBALT(II) AND NICKEL(II) COMPLEXES |