Synthesis, Characterization and bioactivity assessment of mixed monocarboxylic acid complexes

Abstract

A series of new mixed monocarboxylic acid complexes [Co(Amo)(Dic)Cl2], [Cd(Amo)(Dic)Cl2] and [Cu(Amo)(Dic)Cl2] where Amo= Amoxicillin and Dic= Diclofenac were synthesized by refluxing method and characterized using spectroscopic techniques such as infrared and ultraviolet/visible, elemental analysis, conductivity measurements and magnetic susceptibility. The ligands acts bidentate type coordinating to the central metal ion through two donor atoms, typically the carboxylate oxygen and Nitrogen atom from the molecule for Diclofenac while Amoxicillin coordinated to the metal ions through the oxygen of carbonyl group and nitrogen of amine group. Octahedral, Square planar and Tetrahedral geometry has been assigned to the Co(II), Cd(II) and Cu(II) complexes respectively. Towards the in vitro biological potentials, the ligands and metal complexes were screened for antibacterial and anagelsic activities. The complexes were found to have more activities when compared to their free parent ligands. This research work concluded that the mixed complexes showed promising activity against the selected organisms and as such exhibit candidates for treatment of ailments.