MIXED SULPHANILIC ACID - PHTHALIC ANHYDRIDE METAL DRUG COMPLEXES: CHELATION, PHYSICO-CHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY

Abstract

Five metal complexes of mixed sulphanilic acid-phthalic anhydride were synthesized using standard methods. They were characterized by some analytical spectroscopic techniques including conductivity measurement, elemental analysis, infrared spectroscopy, atomic absorption spectroscopy, magnetic moment and thermal studies. The ligands act as bidentate. The conductivity measurements, which were within the range of 12-20 Ω-1 Cm-1 Mol-1, indicated that the complexes were electrolytes. Based on the magnetic moment and the thermal analysis, the complexes were found to be in octahedral geometry. Regions within 3400–3500 cm–1 in the complexes confirmed the presence of crystallization water. Bands at 500-650 cm–1 were attributed to the modes of vibration (M–L). Coordination occurred through the oxygen of the sulphone group and nitrogen of the amine group. In pthalic anhydride, binding site occurred at the oxygen of the carbonyl group and oxygen of the C-O group. The complexes were screened and evaluated for antimicrobial activity against some isolated organisms. From the results, the complexes were found to be more potent and active than their parent free ligands. This research work helped to produce more potent drugs which will be resistant to the organisms.