Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.

Abstract

Ethyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 μg/mL respectively. Isolation of the extracts afforded Tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), β-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, ID and 2D NMR and Mass spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with IC50 of 57.27 and 27.56 μg/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF-7 tumor cell lines.